Between 6% and 10% of the population in the US and Europe are being treated with antidepressant medications. However, the adverse effects of antidepressants are significantly underestimated by physicians. Over 80% of patients report experiencing multiple bothersome side effects, leading to high nonadherence rates between 31% and 60%. These side effects, which include gastrointestinal issues, dizziness, weight changes, and reduced sexual desire, can severely impact a patient’s daily life. As a result, 20% of patients find that the drawbacks outweigh the benefits of their treatment.

The incidence of jitteriness syndrome—characterized by an early worsening of anxiety, agitation, and irritability—occurs in up to 65% of patients starting serotonergic or noradrenergic antidepressants, often leading to discontinuation of treatment. Despite the variety of adverse effects ranging from excessive sweating to significant sexual dysfunction, many of which persist or emerge during long-term use, practical management strategies are available. These include slow medication titration, dietary adjustments, and in some cases, supplementary medications to mitigate these effects.

Reference: Sienaert P. Managing the Adverse Effects of Antidepressants. Psychiatric Times. Published July 31, 2014. Accessed June 5, 2024. https://www.psychiatrictimes.com/view/managing-adverse-effects-antidepressants