In a recent video commentary, John Whyte, MD, MPH, and Roger S. McIntyre, MD, FRCPC, discussed the link between obesity and depression, highlighting that these conditions are bidirectional—depression can lead to obesity. Dr. McIntyre emphasized that people with depression are more likely to be obese due to reduced physical activity, psychiatric medications, and biological factors. Their discussion noted that individuals with both conditions often exhibit inflammatory markers and impaired insulin signaling, which can exacerbate cognitive issues and anhedonia.

Dr. McIntyre pointed out that obesity should be treated as a chronic disease, with brain health considerations factored into treatment decisions. He also mentioned the potential benefits of GLP-1 receptor agonists for both metabolic and psychiatric conditions. He stressed the importance of closing the gap between knowledge and practice by screening for both conditions in affected patients and prioritizing treatments that don’t worsen obesity or glucose metabolism. Dr. Whyte concluded by highlighting the need for continued education and practical strategies for clinicians managing these intertwined conditions.

Reference: Whyte J, McIntyre R. Brain & Body: Connecting Depression and Obesity. Medscape. Published April 16, 2024. Accessed July 15, 2024. https://www.medscape.com/s/viewarticle/brain-body-connecting-depression-and-obesity-2024a100076p?form=fpf